Genenta Progresses to Higher Dosing Cohort in Temferon™ Phase 1/2a Clinical Trial in Glioblastoma Multiforme

No dose limiting toxicity observed in previous three dose level cohorts
Represents a 50% higher dose than highest prior level
Update of guidance for trial

MILAN, Italy and NEW YORK, May 04, 2022 (GLOBE NEWSWIRE) -- Genenta Science (NASDAQ:GNTA), a clinical-stage biotechnology company pioneering the development of hematopoietic stem progenitor cell immuno-gene therapy for cancer, announces that its ongoing trial of Temferon™ in glioblastoma multiforme patients who have an unmethylated MGMT gene promoter (uMGMT-GBM) has escalated to the next planned dose. With no drug-limiting toxicities observed at lower doses, Genenta has now dosed the first patient in a new cohort (cohort 6) with 3.0 x 10⁶ Temferon cells per kilogram, 50% higher than the next highest prior level. One further-escalated dosing level is planned for the Phase 1 segment of the Phase 1/2a trial (cohort 7). Genenta now expects to complete the enrollment and dosing of patients in cohorts 6 and 7 by the end of the first half of 2023.